Vitamin D Science

Vitamin D Research

Vitamin D is one of the oldest hormones, having been produced by life forms for over 750 million years. Phytoplankton, zooplankton, and most plants and animals that are exposed to sunlight have the capacity to make vitamin D. In humans, vitamin D is critically important for the development, growth, and maintenance of a healthy body, from birth until death.

We invite you to browse the various studies to be found in the sections below and see for yourself the scientific evidence of just how vital vitamin D cholecalciferol is to life. To view listing of research abstracts for an area of interest, click on corresponding heading below.

Research Areas

• Autism Research has shown that low maternal vitamin D3 has important ramifications for the developing brain. Vitamin D is a steroid hormone with many important functions in the brain, mediated through the nuclear vitamin D receptor (VDR). Disfunctional VDR demonstrate altered emotional behavior and specific motor deficits.
• Autoimmune Illness Researchers are discovering an increasing number of links between the immune, nervous, and endocrine systems. Hormones of the endocrine system, such as vitamin D, help the immune and nervous systems defend the body, with defects in this intricate system leading to autoimmune disorders.
• Best Science Breakthrough science that has played a significant role in broadening humanity's understanding of vitamin D and its importance in the maintenance of health.
• CancerVitamin D inhibits inappropriate cell division and metastasis, reduces blood vessel formation around tumors, and regulates proteins that affect tumor growth. It also enhances anti-cancer actions of immune system chemicals and chemotherapy drugs.
• Chronic Pain Vitamin D deficiency is a major contributor to chronic low back pain as well as persistent, nonspecific musculoskeletal pain.
• Cognitive Function Recent research indicates vitamin D deficiency is associated with low mood and cognitive impairment in the elderly.
• Commentaries and Editorials Commentaries and editorials written by vitamin D scientists and experts as published in the medical journals.
• Diabetes Vitamin D helps maintain adequate insulin levels. Preliminary evidence suggests supplementation can increase insulin levels in people with type 2 diabetes. Prolonged supplementation may help reduce blood sugar levels.
• Heart Disease Studies have indicated reduced ultraviolet B exposure in CHF patients during childhood, adolescence, and early adulthood. Activated vitamin D has been shown to increase survival in patients with cardiovascular disease.
• Hypertension Clinical and experimental data support the view that vitamin D metabolism is involved in blood pressure regulation and other metabolic processes.
• Melanoma An inability to tan is the number one risk factor for melanoma. Those who tan easily or who have darker skin are far less likely to develop the disease. A new theory is that melanoma is actually caused by sunlight (vitamin D) deficiency and that safe sun exposure actually helps prevent the deadly disease.
• Mental IllnessVitamin D deficiency has been implicated in various psychiatric and neurologic disorders.
• Miscellaneous Vitamin D has been implicated in the pathology of various other health disorders including influenza, psoriasis, gout, otosclerosis, interstitial cystitis, decreased pulmonary function, thrombosis, chronic kidney disease, pancreatitis, rheumatology, hepatitis B infections, hemochromatosis, and gastrointestinal diseases—just to name a few.
• Multiple Sclerosis Vitamin D supplementation may help prevent the development of MS as well as provide for additional treatment.
• Muscular Weakness and Falls Specific receptors for vitamin D have been identified in human muscle tissue. Cross-sectional studies show that elderly persons with higher vitamin D serum levels have increased muscle strength and a lower number of falls.
• Obesity Serum vitamin D is significantly lower in obese individuals, putting them at increased risk for the many health disorders related to vitamin D deficiency.
• Osteoarthritis Low intake and low serum levels of vitamin D appear to be associated with an increased risk for progression of osteoarthritis.
• Osteoporosis Vitamin D deficiency is extremely prevalent in the elderly. Most often the first symptoms are caused by myopathy with muscle pain, fatigue, muscular weakness, and gait disturbances. More severe deficiency causes osteomalacia with deep bone pain, reduced mineralization of bone matrix, and low-energy fractures.
• Parathyroid Function Low plasma vitamin D3 is quite common in patients with parathyroid disease.
• Pharmacology Though several vitamin D analogues have been shown to be somewhat effective in various studies, the effectiveness of plain vitamin D3 cholecalciferol continues to remain superior.
• Physiology Since its discovery, the nuclear vitamin D receptor (VDR) has been found to be present in over thirty tissues and organs of man, indicating a broad sphere of influence over health and vitality.
• Pregnancy and Lactation Studies indicate human milk contains inadequate levels of vitamin D and that routine vitamin D supplementation is advisable for breast-fed infants who are deprived of sunlight exposure.
• Requirements For adults, the 5 microgram (200 IU) vitamin D recommended dietary allowance may prevent osteomalacia in the absence of sunlight, but more is needed to help prevent osteoporosis and secondary hyperparathyroidism. Other benefits of vitamin D supplementation are implicated epidemiologically: prevention of some cancers, osteoarthritis progression, multiple sclerosis, and hypertension.
• Reviews Peer-reviewed papers on vitamin D.
• Toxicity One of the least toxic substances to humans, overdose of vitamin D3 doesn't occur until more than 100 times (approximately one bottle of vitamin D3 tablets) the daily RDA has been taken daily for several months. Acute, one-time overdoses require over 50 mg (10,000 times the RDA).
• Treatment Vitamin D has proven to be a safe and effective treatment for a wide range of health disorders.
• UV ExposureSunlight has an enormous impact on health via the skin's neuroendocrine system. Exposure to UVB enables the body to build a strong skeletal structure, heart, and muscles as well as optimize the immune system and utilization of sugar. Compared with nontanners, tanners have been found to have robust levels of 25-hydroxyvitamin D at winter's end and, as a result, higher bone density.
• Veterinary Veterinary Research wherein vitamin D is listed as a factor.
• Vitamin D Deficiency Vitamin D Deficiency is a world-wide epidemic, with over one billion people at risk for its associated diseases.
• Worst Science The Vitamin D Council reviews three studies which, due to their faulty science, have done a grave disservice to humanity by preventing adequate vitamin D nutrition.